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Generalised tonic-clonic and simplepartial seizures In large comparative trials,considering both efficacy and toxicity, carbama-zepine and phenytoin have scored highest,phenobarbitone was intermediate, while primi-done was lowest among the older drugs.Carbamazepine was the best in partial seizures,while valproate was equally effective insecondarily GTCS. Hensel M, Schneeweiss A, Sinn HP, Egerer G, Solomayer E, Haas R et al (2002) P53 is thestrongest predictor of survival in high-risk primary breast cancer patients undergoing high-dose chemotherapy with autologous blood stem cell support. Propranolol controlsventricular rate in atrial fibrillation and flutter,but only occasionally restores sinus rhythm.Esmolol is an alternative drug for paroxysmalsupraventricular tachycardia (see Ch. However, if the PaCO2 is acutelyelevated, a PaO2 of less than 100 mmHg will besuf?cient to elicit an increase in respiratory drive.In conditions with chronic CO2 retention, such asbronchopulmonary dysplasia (BPD) and late-stage cystic ?brosis, arterial hypoxemia becomesthe primary stimulus to ventilation.

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